Objective: This study aims to assess the health-related quality of life (HRQoL) of patients with chronic kidney disease (CKD) at a charity in Salgueiro, Brazil, in order to support the design of public policies that improve the quality of life. life. Method: Methodologically, it is a descriptive quantitative study, with a prospective transversal cohort approach. The instrument used was the Health Utilities Index (HUI), in which patients on hemodialysis self-evaluated and had their health status assessed by the responsible physicians. Theoretical basis: There are few studies evaluating the impact of medical treatment on the HRQoL of patients in Brazil, mainly in relation to CKD. In this way, this study was based on several works that approach the subject, such as Romão Junior (2004), Furlong et al. (2001), Rodrigues (2011), Del Nero (2002), Sesso et al. (2016), Carvalho (2012) and Melo et al. (2000). Results: The results showed that the majority of patients and doctors considered that the treatment impaired health-related quality of life. Conclusions/contributions: The results of the research suggest that managers of basic public health policies can launch measures that aim to make the community aware of the problems that most cause CKD, such as hypertension and diabetes.